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Severe and persistent disability viagra discount often undermines the life-saving benefits of cancer viagra jelly treatment. Pain and fatigue -- together with sensory, motor, and cognitive disorders -- are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments worldwide.A new study by Georgia Tech researchers in the lab of Timothy C. Cope has found a novel pathway for understanding why these debilitating conditions happen for cancer patients and why scientists should focus on all of the possible neural processes that deliver sensory or motor problems to a patient's brain -- including the central nervous system -- and not just the "peripheral degeneration of sensory neurons" that occurs away from the center of the body.The new findings "Neural circuit mechanisms of sensorimotor viagra discount disability in cancer treatment" are published in the Proceedings of the National Academy of Sciences (PNAS) and could impact development of effective treatments that are not yet available for restoring a patient's normal abilities to receive and process sensory input as part of post cancer treatment, in particular.Stephen N.
(Nick) Housley, a postdoctoral researcher in the School of Biological Sciences, the Integrated Cancer Research Center, and the Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech, is the viagra discount study's lead author. Co-authors include Paul Nardelli, research scientist and Travis Rotterman, postdoctoral fellow (both of the School of Biological Sciences), along with Timothy Cope, who serves as a professor with joint appointments in the School of Biological Sciences at Georgia Tech and in the Coulter Department of Biomedical Engineering at Emory University and Georgia Tech.Neurologic consequences"Chemotherapy undoubtedly negatively influences the peripheral nervous system, which is often viewed as the main culprit of neurologic disorders during cancer treatment," shares Housley.
However, he says, for the nervous system to operate normally, viagra discount both the peripheral and central nervous system must cooperate. advertisement "This occurs through synaptic communication between neurons. Through an elegant series of studies, we show that those hubs of communication in the central nervous system are also vulnerable to cancer treatment's adverse effects," Housley shares, adding that the findings force "recognition of the numerous places throughout the nervous system that we have to treat if we ever want to fix the neurological consequences of cancer treatment -- because correcting any viagra discount one may not be enough to improve human function and quality of life.""These disabilities remain clinically unmitigated and empirically unexplained as research concentrates on peripheral degeneration of sensory neurons," the research team explains in the study, "while understating the possible involvement of neural processes within the central nervous system.
The present findings demonstrate functional defects in the fundamental properties of information processing localized within the central nervous system," concluding that "long-lasting sensorimotor and possibly other disabilities induced by cancer treatment result from independent neural defects compounded across both peripheral and central nervous systems."Sensorimotor disabilities and 'cOIN'The research team notes that cancer survivors "rank sensorimotor disability among the most distressing, long-term consequences of chemotherapy. Disorders in gait, balance, and skilled movements viagra discount are commonly assigned to chemotoxic damage of peripheral sensory neurons without consideration of the deterministic role played by the neural circuits that translate sensory information into movement," adding that this oversight "precludes sufficient, mechanistic understanding and contributes to the absence of effective treatment for reversing chemotherapy-induced disability."Cope says the team resolved this omission "through the use of a combination of electrophysiology, behavior, and modeling to study the operation of a spinal sensorimotor circuit in vivo" in a rodent model of "chronic, oxaliplatin (chemotherapy)-induced neuropathy. COIN."Key sequential events were studied in the encoding of "propriosensory" information (think kinesthesia.
The body's ability to sense viagra discount its location, movements, and actions) and its circuit translation into the synaptic potentials produced in motoneurons. advertisement In the "cOIN" rats, the team noted multiple classes of propriosensory neurons expressed defective firing that reduced accurate sensory representation of muscle mechanical responses to stretch, adding that accuracy "degraded further in the translation of propriosensory signals into synaptic potentials as a result of defective mechanisms residing inside the spinal cord."Joint expression, independent defects"These sequential, peripheral, and central defects compounded to drive the sensorimotor circuit into a functional collapse that was consequential in predicting the significant errors in propriosensory-guided movement behaviors demonstrated here in our rat model and reported for people with cOIN," Cope and Housley report. "We conclude that sensorimotor disability induced by cancer treatment emerges from the joint expression of independent defects occurring in both peripheral and central elements of sensorimotor circuits.""These findings have broad impact on the scientific field and on clinical management of neurologic consequences of cancer viagra discount treatment," Housley says.
"As both a clinician and scientist, I can envision the urgent need to jointly develop quantitative clinical tests that have the capacity to identify which parts of a patient nervous system are impacted by their cancer treatment."Housley also says that having the capacity to monitor neural function across various sites during the course of treatment "will provide a biomarker on which we can optimize treatment -- e.g. Maximize anti-neoplastic effects while minimizing the adverse effects," adding that, as we move into the next generation cancer viagra discount treatments, "clinical tests that can objectively monitor specific aspects of the nervous system will be exceptionally important to test for the presence off-target effect."How can we shift from a state of inattentiveness to one of highest attention?. The locus coeruleus, literally the "blue spot," is a tiny cluster of cells at the base of the brain.
As the main source of the viagra discount neurotransmitter noradrenaline, it helps us control our attentional focus. Synthesizing evidence from animal and human studies, scientists at the Max Planck Institute for Human Development and the University of Southern California have now developed a novel framework describing the way the blue spot regulates our brain's sensitivity to relevant information in situations requiring attention. Their findings have viagra discount been published in an opinion article in the journal Trends in Cognitive Sciences.Our attention fluctuates.
Sometimes, we are distracted and things slip by our awareness, while at other times we can easily focus on what is important. Imagine you are walking home after a viagra discount day at work. Perhaps you are preparing the list of groceries to buy for dinner in your mind -- you are in a state of inattentiveness.
However, when a viagra discount car you did not notice suddenly honks, you are readily able to redirect your attention and respond to this new situation. But how does the brain shift from a state of inattentiveness to one of focused attention?. During states of inattentiveness, our brains are governed by slow, rhythmic fluctuations of viagra discount neural activity.
In particular, neural rhythms at a frequency around 10 Hertz, termed alpha oscillations, are thought to suppress the active processing of sensory inputs during inattentiveness. Thus, alpha oscillations can be viagra discount understood as a filter that regulates our brain's sensitivity for external information. "While the link between the waxing and waning of alpha oscillations and attention has been established for some time, less is known about what makes these rhythmic firing patterns come and go," says Markus Werkle-Bergner, Senior Scientist at the Center for Lifespan Psychology at the Max Planck Institute for Human Development and coauthor on the opinion article.To explore this question, the researchers focused on the blue spot (locus coeruleus), a tiny cell structure that is located in the brainstem, hidden deep under the cortex.
This cell cluster is only about 15 viagra discount millimeters in size, but it is connected to most of the brain via an extensive network of long-ranging nerve fibers. The blue spot is made up of neurons that are the main source of the neurotransmitter noradrenaline. By regulating neural communication, noradrenaline contributes to the control of stress, memory, and attention."Due viagra discount to its small size and its location deep in the brainstem, it was previously almost impossible to investigate the noradrenergic nucleus non-invasively in living humans.
Fortunately, over the past years, animal research has revealed that fluctuations in pupil size are linked to the activity of the blue spot. Thus, our eyes can be regarded as a window to a brain region that long seemed inaccessible," says Mara Mather, professor of Gerontology at the University of Southern California and coauthor on the opinion article.To study whether the blue viagra discount spot's noradrenaline could be one factor regulating alpha oscillations, the researchers combined recordings of pupil size and neural oscillations while participants solved a demanding attention task. As expected, during moments of larger pupil size, indicative of higher noradrenergic activity, alpha oscillations disappeared.
Moreover, participants who showed stronger pupil and alpha responses were better viagra discount at solving the attention task. These findings, that were published 2020 in an article in the Journal of Neuroscience, suggest that by modulating alpha oscillations, the blue spot can help us focus our attention.What remained unanswered in this study is how noradrenaline influences alpha oscillations. To approach this question, the authors additionally turned to previous animal research that recorded neural activity directly from neurons in the thalamus, a region in the middle of the brain that functions viagra discount as a pacemaker of the alpha rhythm.
Importantly, the rhythmic firing of these neurons at rest gives rise to the cortical alpha oscillations seen during states of inattentiveness. However, adding noradrenaline to these neurons viagra discount abolishes their rhythmicity."Assembling the findings across studies, we were able to describe how noradrenaline and the thalamus might interact to control alpha rhythmic activity. We suggest that the blue spot's noradrenaline regulates our brain's sensitivity to process relevant information by suppressing alpha generators in the thalamus," says Martin Dahl, postdoctoral researcher at the Center for Lifespan Psychology, Max Planck Institute for Human Development, and the University of Southern California and first author on the opinion article.Thus, during situations requiring a sudden shift in attention, a surge of noradrenaline helps us refocus -- and quickly dodge the approaching car.Further long-term studies that assess both the locus coeruleus and thalamus in the same participants may be able to shed new light on the neural mechanisms of attention and its decline in aging and disease.When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found.This protective impact was found even in people whose brains at autopsy were riddled with toxic proteins associated with Alzheimer's and other neurodegenerative diseases."Our work is the first that uses human data to show that synaptic protein regulation is related to physical activity and may drive the beneficial cognitive outcomes we see," said Kaitlin Casaletto, PhD, an assistant professor of neurology and lead author on the study, which appears in the January 7 issue of Alzheimer's &.
Dementia. The Journal of the Alzheimer's Association.The beneficial effects of physical activity on cognition have been shown in mice but have been much harder to demonstrate in people.Casaletto, a neuropsychologist and member of the Weill Institute for Neurosciences, worked with William Honer, MD, a professor of psychiatry at the University of British Columbia and senior author of the study, to leverage data from the Memory and Aging Project at Rush University in Chicago. That project tracked the late-life physical activity of elderly participants, who also agreed to donate their brains when they died."Maintaining the integrity of these connections between neurons may be vital to fending off dementia, since the synapse is really the site where cognition happens," Casaletto said.
"Physical activity -- a readily available tool -- may help boost this synaptic functioning."More Proteins Mean Better Nerve Signals advertisement Honer and Casaletto found that elderly people who remained active had higher levels of proteins that facilitate the exchange of information between neurons. This result dovetailed with Honer's earlier finding that people who had more of these proteins in their brains when they died were better able to maintain their cognition late in life.To their surprise, Honer said, the researchers found that the effects ranged beyond the hippocampus, the brain's seat of memory, to encompass other brain regions associated with cognitive function."It may be that physical activity exerts a global sustaining effect, supporting and stimulating healthy function of proteins that facilitate synaptic transmission throughout the brain," Honer said.Synapses Safeguard Brains Showing Signs of DementiaThe brains of most older adults accumulate amyloid and tau, toxic proteins that are the hallmarks of Alzheimer's disease pathology. Many scientists believe amyloid accumulates first, then tau, causing synapses and neurons to fall apart.Casaletto previously found that synaptic integrity, whether measured in the spinal fluid of living adults or the brain tissue of autopsied adults, appeared to dampen the relationship between amyloid and tau, and between tau and neurodegeneration."In older adults with higher levels of the proteins associated with synaptic integrity, this cascade of neurotoxicity that leads to Alzheimer's disease appears to be attenuated," she said.
"Taken together, these two studies show the potential importance of maintaining synaptic health to support the brain against Alzheimer's disease." Story Source. Materials provided by University of California - San Francisco. Original written by Robin Marks.
Note. Content may be edited for style and length..
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With one confirmed case and four presumptive cases of monkeypox in the U.S., clinicians should continue to be on high alert if their patients report new onset of rash, especially in the genital or perianal area, CDC staff said Monday.The one confirmed viagra discount case in Massachusetts had over 200 close contacts, the majority of whom were healthcare workers, said Capt. Jennifer McQuiston, DVM, deputy director of CDC's viagra discount Division of High Consequence Pathogens and Pathology. Right now, contacts of known cases, including healthcare providers, are being vaccinated "if they fall into a high-risk category and warrant" vaccination, she said.The other four presumptive cases -- one in New York City, one in Florida, and two in Utah -- have tested positive for orthopox viagra, but McQuiston explained that only CDC can verify if the specimen is monkeypox (or as one reporter put it, "monkeypox until proven otherwise").
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Those with immunosuppression will likely face a more severe clinical course, viagra discount such as prolonged illness, larger lesions, and more bacterial s, she added.CDC staff said there are two live-viagra smallpox treatments available, which appear to work on monkeypox. The newer treatment Jynneos, which is a non-replicating treatment with fewer adverse events, and ACAM2000, a replicating treatment with a higher chance of adverse events, especially among immunocompromised individuals and those with atopic dermatitis.Brooks added that while data from people living with HIV and monkeypox are very limited, those with well-controlled HIV will likely do as well as "anyone else" with the treatment. Antivirals are viagra discount also available for those at risk of severe disease.There are about a thousand doses of Jynneos available, but production is expected to be ramped up quickly in the coming weeks, McQuiston noted.
There are about 100 million doses of ACAM2000 available.CDC is undertaking a time-tested strategy used to treat infectious disease outbreaks around the world. Isolate, test, viagra discount and contact trace. Brooks stressed that contact tracing viagra discount is effective at limiting the spread of this monkeypox outbreak."We want to encourage people to come forward and urge them to seek care," he said.
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UK health https://kompatech.de/buy-cheap-symbicort-online/ secretary Sajid Javid has set out a digital agenda to harness technological breakthroughs and drive transformation in the NHS and social care.Speaking at the HSJ Digital Transformation Summit (24 viagra contraindications Feb), Javid announced a digital health plan will be published in Spring, building on lessons from the viagra.He outlined four priorities for digital. Ensuring the NHS is set up properly to succeed, levelling up across the NHS and social care, pursuing personalisation, viagra contraindications and making âbig breakthrough betsâ on emerging technologies and data.By December 2023, Javid aims for 90% of NHS trusts to have electronic patient record (EPR) systems, and the remaining 10% to be in the process of implementing them. He said that one in five trusts currently do not have EPRs, which he called âthe essential prerequisite for a modern, viagra contraindications digital NHS.âThe health secretary added that he wanted 80% of social care providers to adopt digital records for social care by March 2024. Currently 40% of social care providers are still paper based.Javid also set out an ambition for 75% of adults in England to be registered for the NHS App by March 2024, emphasising the app was âfor life not just for erectile dysfunction treatment.â Currently 50% of adults in England (around 24 million) use the app.Another topic was the need to address the âstark diversity gapâ in clinical trials, which Javid said work had started on, with the launch of a review into potential bias in medical devices being led by Dame Margaret Whitehead.WHY IT MATTERSJavidâs speech came on the day all remaining legal erectile dysfunction treatment restrictions in England were lifted, as part of the âLiving with erectile dysfunction treatmentâ plan.The digital agenda aims to help embed technologies to help clear the erectile dysfunction treatment backlog and reduce waiting lists.With an increasingly ageing population, Javid suggested that remote monitoring technology used during erectile dysfunction treatment could help offer âdignified and independent careâ to people, in viagra contraindications their own home, minimising time spent in clinical settings.THE LARGER CONTEXTEarlier this month interim arrangements were revealed for the NHS Englandâs new transformational directorate, which will incorporate NHSX and NHS Digital.
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As we move through the third year of when can i take viagra after taking cialis the viagra, the specter of long erectile dysfunction treatment Symbicort price per pill or post-erectile dysfunction treatment conditions has emerged as a matter of great concern, especially since so much is still unknown. The Centers for Disease Control and Prevention estimates that the diseaseâcharacterized by an array of symptoms involving multiple organ systems and persisting at least one month post-âis affecting 1 in 5 adults, or up to 23 million people.While the federal response has coalesced to a greater degree over the last few months, the U.S. Has a long way to go in terms of developing when can i take viagra after taking cialis uniform guidelines to diagnose, manage and track long erectile dysfunction treatment, and building structural supports for those suffering from it. Encouragingly, the Biden administration has accelerated enrollment of 40,000 individuals into the landmark National Institutes of Health study of long erectile dysfunction treatment, Researching erectile dysfunction treatment to Enhance Recovery (RECOVER), which was launched last year. The administration has also pledged to focus when can i take viagra after taking cialis its efforts on underserved communities most affected by acute and long erectile dysfunction treatment.
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To capture an accurate count and distribution of long erectile dysfunction treatment patients, the federal government could mandate provider reporting through its national surveillance and reporting system, currently used to track certain communicable s.In order to report and accurately count cases, diagnostic criteria must be clarified and reporting should be standardized. Because this is an emerging condition and has such variable presentation, many providers are not clear on what constitutes a formal case. How and when should it be coded in the when can i take viagra after taking cialis electronic health record?. What are the clinical protocols for management?. As researchers work to answer these questions, information should be broadly disseminated and easy for clinicians and patients to access, without having to perpetually mine government sources such as the CDC website or search for emerging studies in academic publications.To even identify long when can i take viagra after taking cialis erectile dysfunction treatment in the first place can require significant effort, especially among patients with sporadic access to care.
Patients may seek care for the first time long after chronic symptoms have developed, and may not have confirmed they ever had erectile dysfunction treatment in the first place. Once we've confirmed a when can i take viagra after taking cialis past , other diseases with similar symptoms must be ruled out. Then, because long erectile dysfunction treatment manifests differently in each patient and no widely beneficial treatment yet exists, treatments must be tailored and thus can vary widely. When specialty care or therapies are needed, access to expert care teams for post-erectile dysfunction treatment conditions is currently limited to academic medical centers with busy post-erectile dysfunction treatment condition clinics that generally require insurance. Given the multilevel barriers to care for underserved patients and the increased use of at-home tests, additional investment in the "test to treat" model is essential to identify and track cases and to provide timely treatment and follow-up.Models for long erectile dysfunction treatment when can i take viagra after taking cialis care must be tested and built.
The Department of Health and Human Services could sponsor demonstration projects to show what these might look like. Trained, multidisciplinary providers armed with appropriate knowledge of promising therapiesâsuch as pulmonary rehab and specialized cognitive behavioral therapy for brain fogâcould work in and with health centers to fill these gaps and treat patients in communities hardest hit.Public health messaging should be revamped when can i take viagra after taking cialis and reactivated so patients with long erectile dysfunction treatment are aware of available resources and how to "show up" for care in a timely and proactive way.Clear coding and reimbursement guidelines for long erectile dysfunction treatment must be established, and reimbursement itself must be fair and adequate for a range of long erectile dysfunction treatment-related conditions treated by multidisciplinary providers, including behavioral health. This is particularly important for safety-net providers such as community health centers, which serve a large share of publicly insured patients whose care is reimbursed at lower rates. Additional funding should be allocated to health centers and other safety-net providers to ensure they can continue treating uninsured patients struggling with long erectile dysfunction treatment without exhausting limited resources..
As we move Symbicort price per pill through the third year of the viagra, the specter of long erectile dysfunction treatment or post-erectile dysfunction treatment conditions has emerged as a matter of great concern, especially since viagra discount so much is still unknown. The Centers for Disease Control and Prevention estimates that the diseaseâcharacterized by an array of symptoms involving multiple organ systems and persisting at least one month post-âis affecting 1 in 5 adults, or up to 23 million people.While the federal response has coalesced to a greater degree over the last few months, the U.S. Has a long way to go in terms of developing uniform guidelines to diagnose, manage and track long erectile dysfunction treatment, and viagra discount building structural supports for those suffering from it.
Encouragingly, the Biden administration has accelerated enrollment of 40,000 individuals into the landmark National Institutes of Health study of long erectile dysfunction treatment, Researching erectile dysfunction treatment to Enhance Recovery (RECOVER), which was launched last year. The administration has also pledged to focus its efforts on underserved communities most affected viagra discount by acute and long erectile dysfunction treatment. A good place to start for NIH would be to actively recruit for RECOVER at community health centers nationwide.Community health centers serve low-income patients, two-thirds of whom are people of color.
Because these groups have been disproportionately impacted by erectile dysfunction treatment, they are also more likely to suffer from post-erectile dysfunction treatment conditions. In its efforts to assist health centers to identify and treat patients who are by definition under-resourced, the National Association of Community Health Centers viagra discount has accumulated some valuable lessons and recommendations on how best to centralize and coordinate a holistic response.The first step in tackling any problem is to measure its size and identify who is most affected. This has been difficult with long erectile dysfunction treatment because comprehensive data about its prevalenceânot to mention its characteristics and clinical courseâis currently lacking.
Primary-care providers are not incentivized to retrieve and funnel data on this disease, which could be viagra discount corrected through public policy measures. To capture an accurate count and distribution of long erectile dysfunction treatment patients, the federal government could mandate provider reporting through its national surveillance and reporting system, currently used to track certain communicable s.In order to report and accurately count cases, diagnostic criteria must be clarified and reporting should be standardized. Because this is an emerging condition and has such variable presentation, many providers are not clear on what constitutes a formal case.
How and when should it be coded viagra discount in the electronic health record?. What are the clinical protocols for management?. As researchers work to answer these questions, information should be broadly viagra discount disseminated and easy for clinicians and patients to access, without having to perpetually mine government sources such as the CDC website or search for emerging studies in academic publications.To even identify long erectile dysfunction treatment in the first place can require significant effort, especially among patients with sporadic access to care.
Patients may seek care for the first time long after chronic symptoms have developed, and may not have confirmed they ever had erectile dysfunction treatment in the first place. Once we've confirmed a past , other diseases with similar symptoms must be ruled out viagra discount. Then, because long erectile dysfunction treatment manifests differently in each patient and no widely beneficial treatment yet exists, treatments must be tailored and thus can vary widely.
When specialty care or therapies are needed, access to expert care teams for post-erectile dysfunction treatment conditions is currently limited to academic medical centers with busy post-erectile dysfunction treatment condition clinics that generally require insurance. Given the multilevel barriers to care for underserved viagra discount patients and the increased use of at-home tests, additional investment in the "test to treat" model is essential to identify and track cases and to provide timely treatment and follow-up.Models for long erectile dysfunction treatment care must be tested and built. The Department of Health and Human Services could sponsor demonstration projects to show what these might look like.
Trained, multidisciplinary providers armed with appropriate knowledge of promising therapiesâsuch as pulmonary rehab and specialized cognitive behavioral therapy for brain fogâcould work in and with health centers to fill these gaps and treat patients in communities hardest hit.Public health messaging should be revamped and reactivated so patients with long erectile dysfunction treatment are aware of available resources and how to "show up" for care in a timely and viagra discount proactive way.Clear coding and reimbursement guidelines for long erectile dysfunction treatment must be established, and reimbursement itself must be fair and adequate for a range of long erectile dysfunction treatment-related conditions treated by multidisciplinary providers, including behavioral health. This is particularly important for safety-net providers such as community health centers, which serve a large share of publicly insured patients whose care is reimbursed at lower rates. Additional funding should be allocated to health centers and other safety-net providers to ensure they can continue treating uninsured patients struggling with long erectile dysfunction treatment without exhausting limited resources..
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I even ordered some baklava to bring home. My family and I loved it!. "The restaurant is located at 29 Route 303 in the Tappan Plaza in Tappan.For information, call 845-680-6642. Click here to follow Daily Voice Somers and receive free news updates..
Open for only three months, a new Afghan and Mediterranean restaurant in the Hudson Valley is viagra discount receiving high ratings from foodies and online reviewers.Located in Rockland County, Mazadore Kebab, in the Tappan Plaza in Tappan, is quickly gaining a reputation for its fresh and quality ingredients with plenty of fragrant seasonings.But operating a top-notch restaurant is nothing new for the owners who owned Khyber Pass Cipro online usa restaurant for 22 years in St Marks Place, in Manhattan, before the viagra forced them to close.The menu features what you would expect from a kebab restaurant, plenty of different kababs as well as dumplings, tabbouleh, and pumpkin saute.The prices are very moderate and reviewers rave about the service.Some menu options that seem to be favorites include chicken shawarma, shish kebab, and dumplings.One Yelper from Tappan put it this way. "I have been wanting to try this place since I heard they opened just a few weeks ago and I was not disappointed!. !.
I was greeted warmly by the super sweet owner who took my order promptly. "I had some trouble deciding what to pick because everything looked good (and VERY reasonably priced). I ended up getting the chicken shawarma which comes with either rice or salad.
I chose salad. I also got French fries and two drinks. "Everything was freshly cooked right in front of me but I didn't have to wait long at all.
The food was DELICIOUS and the portions were sizable. So fresh and well-seasoned. I particularly liked the sauces on the chicken and the minty dressing on the salad.
I even ordered some baklava to bring home. My family and I loved it!. "The restaurant is located at 29 Route 303 in the Tappan Plaza in Tappan.For information, call 845-680-6642.
Click here to follow Daily Voice Somers and receive free news updates..